Scrl Dwn

~~ 2023 ~~


Y Suber, MNA Alam, K Nakos, P Bhakt, ET Spiliotis. Microtubule-associated septin complexes modulate kinesin and dynein motility with differential specificities. Journal of Biological Chemistry. doi:10.1016/j.jbc.2023.105084

J Okletey, D Angelis, TM Jones, C Montagna, ET Spiliotis. An oncogenic isoform of septin 9 promotes the formation of juxtanuclear invadopodia by reducing nuclear deformability. Cell Reports. doi: 10.1016/j.celrep.2023.112893

~~ 2022 ~~


Radler MR, Liu X, Peng M, Doyle B, Toyo-Oka K, Spiliotis ET. Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiation. Curr Bio. doi:10.1016/j.cub.2022.11.043.

Nakos K, Alam MNA, Radler M, Kesisova IA, Yang C, Okletey J, Tomasso MR, Padrick SD, Svitkina TM, Spiliotis ET. Septins mediate a microtubule-actin crosstalk that enables actin growth on microtubules. PNAS. In Press.

Radler MR, Spiliotis ET. Right place, right time - spatial guidance of neuronal morphogenesis by septin septin GTPases. Curr Opinon Neurobiology. 75:102557.

Marenich D, Nakos K, Pompan T, Donovan SJ, Gill A, Patel P, Spiliotis ET, Myers KA. Septins guide noncentrosomal microtubules to promote focal adhesion disassembly in migrating cells. Mol Biol Cell. 33(5):ar40.

~~ 2021 ~~


Devlin L, Okletey J, Perkins G, Bowen JR, Nakos K, Montagna C, Spiliotis ET. Proteomic profiling of the oncogenic septin 9 reveals isoform-specific interactions in breast cancer cells. Proteomics. 21(19):e2100155.

Spiliotis ET, Kesisova IA. Spatial regulation of microtubule-dependent transport of septin GTPases. Trends in Cell Biol. 31(12):979-993.

Spiliotis ET, Nakos K. Cellular functions of actin- and microtubules-associated septins. Curr Biol. 31(10):R651-R666.

Kesisova IA, Robinson BP, Spiliotis ET. A septin GTPase scaffold of dynein-dynactin motors trigger retrograde lysosome transport. J Cell Biol. 220(2):e202005219.

~~ 2020 ~~


Spiliotis ET, McMurray MA. Masters of asymmetry - lessons and perspectives from 50 years of septins. Mol Biol Cell. 31(31):2289-2297.

DeRose BT, Kelley RS, Ravi R, Kokona B, Spiliotis ET, Padrick SB. Production and analysis of a mammalian septin hetero-octamer complex. Cytoskeleton (Hoboken). 77(11):485-499.

Radler MR, Suber A, Spiliotis ET. Spatial control of membrane traffic in neuronal dendrites. Mol Cell Neurosci. 2020;105:103492. doi:10.1016/j.mcn.2020.103492

~~ 2019 ~~


Nakos K, Radler MR, Spiliotis ET. Septin 2/6/7 complexes tune microtubule plus-end growth and EB1 binding in a concentration- and filament-dependent manner. Mol Biol Cell. 2019 Nov 1;30(23):2913-2928. doi: 10.1091/mbc.E19-07-0362

Karasmanis EP, Hwang D, Nakos K, Bowen JR, Angelis D, Spiliotis ET. A Septin Double Ring Controls the Spatiotemporal Organization of the ESCRT Machinery in Cytokinetic Abscission Curr Biol. 2019 Jul 8;29(13):2174-2182.e7. doi: 10.1016/j.cub.2019.05.050

Nakos K, Rosenberg M, Spiliotis ET. Regulation of microtubule plus end dynamics by septin 9. Cytoskeleton (Hoboken). 2019 Jan;76(1): 83–91. Published online 2018 Nov 14. doi: 10.1002/cm.21488

Krokowski S, Lobato-Márquez D, Chastanet A, Pereira PM, Angelis D, Galea D, Larrouy-Maumus G, Henriques R, Spiliotis ET, Carballido-López R, Mostowy S. Septins Recognize and Entrap Dividing Bacterial Cells for Delivery to Lysosomes Cell Host Microbe. 2018 Dec 12; 24(6): 866–874.e4. doi: 10.1016/j.chom.2018.11.005

~~ 2018 ~~


Karasmanis EP, Phan CT, Angelis D, Kesisova IA, Hoogenraad CC, McKenney RJ, Spiliotis ET. Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin Dev Cell. 2018 Jul 16; 46(2): 204–218.e7. doi: 10.1016/j.devcel.2018.06.013

Spiliotis ET. Spatial effects - Site-specific regulation of actin and microtubule organization by septin GTPases J. Cell Sci. 131(1) doi: 10.1242/jcs.207555

~~ 2016 ~~


Angelis D and Spiliotis ET. Septin mutations in human cancers Front. Cell Dev. Biol. 09 November 2016 | https://doi.org/10.3389/fcell.2016.00122

Spiliotis ET, Karasmanis EP, Dolat L. Fluorescence microscopy of actin- and microtubule-associated septins in mammalian cells Methods in Cell Biology Volume 136, 2016, Pages 243–268

Dolat L and Spiliotis ET. Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion J. Cell Biol. 2016 Aug 22 vol. 214 no. 5 517-527

Spiliotis ET, Dolat L. Priming for destruction: septins at the crossroads of mitochondrial fission and bacterial autophagy EMBO reports (2016) 17, 935-937

Bai X, Karasmanis EP, Spiliotis ET. Septin 9 interacts with kinesin KIF17 and interferes with the mechanism of NMDA receptor cargo binding and transport Mol. Biol. Cell January 28, 2016 mbc.E15-07-0493.

~~ 2015 ~~


Spiliotis ET, Dolat L . Septins: cytoskeletal filaments with structural and regulatory functions Encyclopedia of Cell Biology

Smith C, Dolat L, Angelis D, Forgacs E, Spiliotis ET, Galkin VE. Septin 9 exhibits polymorphic binding to F-actin and inhibits myosin and cofilin activity. J. Mol Biol. Volume 427, Issue 20, 9 October 2015

~~ 2014 ~~


Dolat L, Hunyara JL, Bowen JR, Karasmanis EP, Elgawly M, Galkin VE, Spiliotis ET. Septins promote stress fiber-mediated maturation of focal adhesions and renal epithelial motility. J. Cell Biol. 2014 Oct 27 Vol. 207 No. 2 225–235

Dimitrios Angelis, Karasmanis EP, Xiabo Bai, Spiliotis ET. In Silico docking of forchlorfenuron (FCF) to septins suggests that FCF interferes with GTP binding PLoS One 2014 May; 9(5):e96390.

~~ 2013 ~~


Bai X, Bowen JR, Knox TK, Zhou K, Pendziwiat M, Kuhlenbäumer G, Sindelar CV, Spiliotis ET. Novel septin 9 repeat motifs altered in neuralgic amyotrophy bind and bundle microtubules. J. Cell Biol. 2013 Dec 16 Vol. 203 No. 6 895–905

Mostowy S, Bi E, Füchtbauer EM, Goryachev AB, Montagna C, Nagata KI, Trimble WS, Werner HB, Yao X, Zieger B, Spiliotis ET. Highlight: The 5th International Workshop on Septin Biology. Biol Chem. 2013 Dec 12. [EPub ahead of print]

Cui C, Chatterjee B, Lozito TP, Zhang Z, Francis RJ, Yagi H, Swanhart LM, Sanker S, Francis D, Yu Q, San Agustin JT, Puligilla C, Chatterjee T, Tansey T, Liu X, Kelley MW, Spiliotis ET, Kwiatkowski AV, Tuan R, Pazour GJ, Hukriede NA, Lo CW. Wdpcp, a PCP Protein Required for Ciliogenesis, Regulates Directional Cell Migration and Cell Polarity by Direct Modulation of the Actin Cytoskeleton. PLoS Biol. 2013 Nov;11(11):e1001720.

Dolat L, Hu Q, Spiliotis ET. Septin functions in organ system physiology and pathology. Biol Chem. 2013 Oct 10. [Epub ahead of print]

~~ 2012 ~~


Hu J, Bai X, Bowen JR, Dolat L, Korobova F, Yu W, Baas PW, Svitkina T, Gallo G, Spiliotis ET. Septin-driven coordination of actin and microtubule remodeling regulates the collateral branching of axons. Curr Biol. 2012 Jun 19;22(12):1109-15.

Spiliotis ET, Gladfelter AS. Spatial Guidance of Cell Asymmetry: Septin GTPases Show the Way. Traffic. 2012 Feb;13(2):195-203.

~~ 2011 ~~


Bowen JR, Hwang D, Bai X, Roy D, Spiliotis ET. Septin GTPases spatially guide microtubule organization and plus end dynamics in polarizing epithelia. J Cell Biol. 2011 Jul 25;194(2):187-97.

Demay BS, Bai X, Howard L, Occhipinti P, Meseroll RA, Spiliotis ET, Oldenbourg R, Gladfelter AS. Septin filaments exhibit a dynamic, paired organization that is conserved from yeast to mammals. J Cell Biol. 193(6): 1065-81.

~~ 2010 ~~


Qicong Hu, Ljiljana Milenkovic, Hua Jin, Matthew P. Scott, Maxence V. Nachury, Elias T. Spiliotis, and W. James Nelson. A Septin Diffusion Barrier at the Base of the Primary Cilium Maintains Ciliary Membrane Protein Distribution. Science. 2010 Jul 23;329(5990):436-9. Epub 2010 Jun 17.

Spiliotis ET. Regulation of microtubule organization and functions by septin GTPases. Cytoskeleton. 2010 Jun;67(6):339-45.

~~ 2008 ~~


Spiliotis, ET and Nelson, WJ. “Septins and the Mammalian Cytoskeleton”. The Septins, Eds. J. Pringle, P. Hall, H. Russell, Wiley Press, 2008.

Hu Q, Nelson WJ, Spiliotis ET. Forchlorfenuron alters mammalian septin assembly, organization, and dynamics. J Biol Chem. 2008 Oct 24;283(43):29563-71. Epub 2008 Aug 18.

Kitt KN, Hernández-Deviez D, Ballantyne SD, Spiliotis ET, Casanova JE, Wilson JM. Rab14 regulates apical targeting in polarized epithelial cells. Traffic. 2008 Jul;9(7):1218-31. Epub 2008 Apr 21.

Spiliotis ET, Hunt SJ, Hu Q, Kinoshita M, Nelson WJ. Epithelial polarity requires septin coupling of vesicle transport to polyglutamylated microtubules. J Cell Biol. 2008 Jan 28;180(2):295-303. Epub 2008 Jan 21.
Rated as "Must Read" by Faculty1000 Biology.

~~ 2003 - 2007 ~~


Spiliotis ET, Nelson WJ. Here come the septins: novel polymers that coordinate intracellular functions and organization. J Cell Sci. 2006 Jan 1;119(Pt 1):4-10. Review.

Spiliotis ET, Kinoshita M, Nelson WJ. A mitotic septin scaffold required for Mammalian chromosome congression and segregation. Science. 2005 Mar 18;307(5716):1781-5.

Spiliotis ET, Nelson WJ. Spatial control of exocytosis. Curr Opin Cell Biol. 2003 Aug;15(4):430-7. Review.